Asthi-shrinkhala promotes reunion of fractured bones (asthi-yuk, asthi-sandhana-janani). It has been reported to enhance the development of cortical bone and trabecula, and facilitates rapid healing of fracture by influencing early regeneration and quick mineralization of bone. In another study, it was demonstrated to possess anti-osteoporotic action. Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750 mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifene (5.4 mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750 mg/kg), respectively. The findings assessed on the basis of bio-mechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite anti-osteoporotic effect.
Arjuna is a wound-healer (vrana-hara), anti-ischemic (asrajit), and antioxidant (kshayajit). It promotes healing of broken tissues and organs (kshata-ksheena-jit). It is used for the rapid healing of fracture (bhagna-sandhana-kara).